Protein Details: orai-2

Protein ID

ICDB_Pro_1755

Protein Name

orai-2

Gene Name

orai2 tmem142b

Organism

Xenopus laevis (African clawed frog)

Length

257 amino acids

AlphaFoldDB

AF-Q6NZI6-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim1.

Sequence

MSSELNIPVDPSTPAVSERGNKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEMKYGYPQLLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVNESPHDRMHPYIELAWGFSTALGILLFLAEVVLLCWIKFLPIDSALTRNETATTQKPRGNAGWNSALVSTIIMVPVGIIFVIFTIHFYRTLVRHKTERHHQEIEELHKLKVQLDGHDRGINVV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

RefSeq

NP_001084444.1